![]() ![]() This work reveals a multi-dimensional functional lncRNA landscape underlying NSCLC that contains potential therapeutic vulnerabilities. Double-click the icon and Acquire will open in the design as shown overleaf. Users of Leica instruments can be found in many fields: life science research, throughout the manufacturing industry. 7.2.7 known or anticipated sale, merger, or acquisition. A range of specific modules allows configuration of the microscope as a dedicated high-performance tool for almost. Widely recognized for optical precision and innovative technology, Leica Microsystems is one of the market leaders in microscopy: anywhere from stereo to digital microscopy and all the way up to super-resolution, as well as sample preparation solutions for electron microscopy. 3.3.5 Payment will be made by check unless the parties mutually agree to payment by credit card. For easier access to Acquire, drag the icon to the Dock on the Desktop, or create an alias and place the alias on the Desktop. With an intuitive user interface and straightforward navigation, our microscope imaging software guides the user through their workflow, whether fast image acquisition or sophisticated expert analysis. Molecular phenotyping reveals that CHiLL1 and GCAWKR control cellular-level phenotypes via distinct transcriptional networks. Leica Acquire User Manual 7 Overview Starting Acquire Leica Acquire can be started from the Leica Acquire icon in the application folder. A follow-up antisense oligonucleotide (ASO) screen shortlisted two candidates, Cancer Hallmarks in Lung LncRNA 1 ( CHiLL1) and GCAWKR, whose knockdown consistently suppressed cancer hallmarks in two- and three-dimension tumor models. ![]() Altogether, 80 high-confidence oncogenic lncRNAs are active in NSCLC, which tend to be amplified and overexpressed in tumors. Leica Microsystems (Schweiz) AG Max Schmidheiny Strae 201 9435 Heerbrugg LEICA ACQUIRE Leica Acquire is a software environment which allows the acquisition, analysis and processing of high quality digital images using Leica cameras and stereo microscopes on an Apple Mac. Integrative analysis of these data outperforms conventional “dropout” screens in identifying cancer genes while prioritizing disease-relevant lncRNAs with pleiotropic and background-independent roles. We employ pooled CRISPR deletion to perturb 831 lncRNAs detected in KRAS-mutant non-small cell lung cancer (NSCLC) and measure their contribution to proliferation, chemoresistance, and migration across two cell backgrounds. Long noncoding RNAs (lncRNAs) are widely dysregulated in cancer, yet their functional roles in cancer hallmarks remain unclear.
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